Poisoning Treatment India
Early Stage Blood Purification for Paraquat Poisoning : A Multicenter Retrospective Study Poisoning Treatment India Paraquat (PQ) is a water-soluble organic heterocyclic herbicide (1,1-dimethyl-4,4-bipyridine cationic salt) with an apparent distribution volume of 1 liter/kg [1, 2] . PQ is very toxic to human and animals and is without any specific antidote. The oral lethal dose is 1–6 g and the lethal concentration is 3 g/ml [3] . The toxicity of PQ might be due to its accumulation in the alveolar cells resulting in lipid oxidation by free radicals of the cell membranes in the lung, kidney, and liver, and manifesting as pulmonary hemorrhage, edema, fibrosis, and liver and kidney damage [4] . Treatments include emetics, gastric lavage, catharsis, diuretics, reduced glutathione, glucocorticoid, and organ function support [5–7] . The toxicokinetics of PQ in humans is not entirely clear, and most knowledge is obtained from animal studies. The gastrointestinal absorpti